Mouth dissolving tablets (MDT) have the unique property of rapid disintegrating and releasing drug as soon as they come in contact with saliva obviating the requirement of water during administration. The purpose of present investigation work deals with enhancing the solubility of Felodipine, an anti-hypertensive drug and formulating into mouth dissolving tablets. The employed solubility enhancement techniques are solid dispersions and complexation. The polymers used are Beta–cyclodextrins (β-CD), Micro crystalline cellulose (MCC), and Hydroxypropylmethylcellulose (HPMC). Drug and polymer interactions were investigated by using FT-IR and DSC. The prepared Felodipine complexes and solid dispersions were evaluated for bulk density, angle of repose, percentage compressibility and drug content and were formulated into tablets. The prepared tablets were evaluated for hardness, friability, in-vitro dissolution time, wetting time and in-vitro drug release. Among the designed formulations, F4 containing 1:6 ratio of Felodipine and β–CD emerged as best formulation over all due to better disintegration and drug release.
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